Coins dating from the ancient and medieval period, part of the numismatic collection of the MI City Museum of Negotino are exhibited in the showcase located in the central area of ​​the archaeological exhibition. The Numismatic Collection, in the City Museum of Negotino, was established in 2004 and today it is part of the permanent archaeological exhibition. The purpose of its formation is to preserve the cultural heritage in the domain of monetary exchange, in the wider region of the Municipality of Negotino. It consists of 250 coins, most of which are bronze, and the rest are copper, silver, and several gold coins. The contents of this collection in several thematic and chronological parts represent the circulation of coins on the territory of the Municipality of Negotino as part of the monetary system in the Central-Vardar region in the Ancient period and the Middle Ages, i.e. from the 4th century BC until the 14th century AD.

Such a continuous presence of the coins on this territory over a long period of time speaks of the developed money system in the region. This is due to the developed economy as a result of the good location of the municipality on the ancient roadway along the Vardar valley, where important trade relations were taking place and the flow of the cultural values ​​and achievements of other cultural centres (the civilized world) was felt.